We are thrilled to announce the Professional Development Challenge, inspiring you to grow your confidence, network, and professional skills. Check out the challenge activities and let us know your experience! Find updates on our Instagram!
From presenting at BMES to Dr. Moore’s TED Talk releasing, we are celebrating successes big and small for our lab members! See our highlights!
From diving into the fundamentals of materials science to exploring groundbreaking applications of biomaterials, we’ve shared a journey full of innovation, curiosity, and creativity.
An October highlight was attending the 2024 BMES Annual Meeting! Our favorite insights included meeting engineers, receiving feedback, and bringing the excitement of our presentations back into the lab.
Congrats to Dr. Moore for being selected as a 2024 TED Fellow! Watch her TED Talk here!
From fundraising to participating in the walk, we enjoyed supporting the Lupus Foundation of America in September! Enjoy our highlights here!
Dr. Moore teaches Financial Literacy to the UMD LSAMP BRIDGE Program!
Congrats to Chandler on his new paper: Site-Specific Glycosylation Analysis of Murine and Human Fcγ Receptors Reveals High Heterogeneity at Conserved N-Glycosylation Site!
Congrats to Aakanksha on her new paper: Laminin-derived peptide, IKVAV, modulates macrophage phenotype through integrin mediation!
Congrats to Justin on his new paper: Metformin Treatment of Macrophages Increases Microvessel Growth in Three-Dimensional Hydrogel Coculture!
Congrats to Ally for being awarded the UMD MPower Fellowship!
Welcome Ally and Lara to the Moore Lab! We're so excited to have TWO Moore PhD students join the lab!
Welcome Dr. Nana and Dr. Aakanksha (first Moore Lab PhD) as our first Moore Lab Postdocs! We are thrilled to have you both!
Lara leads the lab in supporting Lupus Research by organizing our lab's participation at the 2023 Walk to End Lupus Now in Washington DC!
Congrats to the lab for the NSF CAREER Award! Special shoutout to Aakanksha- her thesis work supported the proposed work!
Congrats to Aakanksha for winning 1st place for her poster in the 2023 UMD Postdoctoral Research Symposium!!
Congrats to the lab for the NSF CAREER Award! Special shoutout to Aakanksha- her thesis work supported the proposed work!
We've been awarded the 3M NTFA for 2023! We are grateful to 3M for their continued support!
While other immune cells are well characterized in their response to biomaterials, this work was the first to characterize how biomaterials influence B cells following injury! We leveraged muscle injury models in mice and compared natural (ECM) vs. synthetic (PCL) biomaterial responses.
Moore, E. Maestas Jr. D. R., Cherry, C. C., et al. Biomaterials direct functional B cell response in a material-specific manner. Science Advances, 7(49), (2021)As humans age, the immune system loses functionality which causes complications in response to infection, wound healing, and increased risk of vascular disease. We model the effects of age on macrophage function in the vasculature by encapsulating human macrophages from elderly (>65) or young (<35) donors with vascular cells in our PEG hydrogel system. We currently are evaluating the differences in age, and will also look to evaluate the influence of sex of macrophage donors as well.
Silberman J, Boehlein J, Abbate T, Moore E: A Biomaterial Model to Assess the Effects of Age in Vascularization. Cells Tissues Organs 2022. doi: 10.1159/000523859. https://pubmed.ncbi.nlm.nih.gov/35249009/Systemic lupus erythematosus (SLE) is a serious autoimmune disease that disproportionately affects women and people of African descent. There are several factors that contribute to the increased risk of SLE in women compared to men, but the mechanisms by which race/ancestry is associated with SLE risk are less well understood. We are characterizing inflammatory properties of immune cells from SLE patients and healthy individuals in order to see whether race/ancestry affects SLE-associated changes.
Ryan, H., Morel, L., and Moore, E. Vascular Inflammation in Mouse Models of Systemic Lupus Erythematosus. Front. Cardiovasc. Med., (2022). https://doi.org/10.3389/fcvm.2022.767450
Generation and characterization of two immortalized dermal fibroblast cell lines from the spiny mouse! Michele's cells are now available at ATCC!
Congrats to the lab for the NSF CAREER Award! Special shoutout to Aakanksha- her thesis work supported the proposed work!
We've been awarded the 3M NTFA for 2023! We are grateful to 3M for their continued support!
Michele and Paulina are spending Summer 2023 at United Therapeutics! We know they're going to do great!
Holly, Michele, Justin, and Alison presented updates from their research at 2023 Society for Biomaterials Annual Conference!
We've been awarded the 3M NTFA for 2023! We are grateful to 3M for their continued support!
Michele and Justin were awarded Honorable Mention STAR Awards from the Society for Biomaterials 2023 Annual conference! Congrats to them both for their hard work!
We've been awarded the 3M NTFA for 2023! We are grateful to 3M for their continued support!
Holly and Justin presented their work at the Department of Rheumatology's grand rounds in March 2023! They did a phenomenal job sharing their work!
Congrats to the lab for the NSF CAREER Award! Special shoutout to Aakanksha- her thesis work supported the proposed work!
Holly, Michele, Justin, and Alison presented updates from their research at 2023 Society for Biomaterials Annual Conference!
We've been awarded the 3M NTFA for 2023! We are grateful to 3M for their continued support!
We are designing 3D polyethylene glycol (PEG)-based hydrogels using ECM-derived peptides to inform cell function via integrin mediation. We aim to control the activation of pro-inflammatory macrophages to prevent chronic inflammation and have designed a biomaterial for the same. Further, we are designing bifunctional biomaterials to promote vessel formation in the macrophage inhibiting hydrogel.
Jha, A., Moore, E. Collagen-derived peptide, DGEA, inhibits pro-inflammatory macrophages in biofunctional hydrogels. Journal of Materials Research (2021) https://doi.org/10.1557/s43578-021-00423-yIn partnership with Dr. Josephine Allen, we investigate the influence of microgravity on macrophage function. We leverage microgravity simulators and molecular biology to characterize macrophage cell function as a result of alterations in gravity.
Ludtka, C., Moore, E., & Allen, J. B. (2021). The Effects of Simulated Microgravity on Macrophage Phenotype. Biomedicines, 9(9), 1205. https://doi.org/10.3390/biomedicines9091205Ludtka, C., Silberman, J., Moore, E. et al. Macrophages in microgravity: the impact of space on immune cells. npj Microgravity 7,13 (2021). https://doi.org/10.1038/s41526-021-00141-z
Congrats to the lab for the NSF CAREER Award! Special shoutout to Aakanksha- her thesis work supported the proposed work!
SOCS1-KIR Peptide in PEGDA Hydrogels Reduces Pro-Inflammatory Macrophage Activation! Read about our collaboration with Dr. Larkin!
We've been awarded the 3M NTFA for 2023! We are grateful to 3M for their continued support!
We've been awarded the 3M NTFA for 2023! We are grateful to 3M for their continued support!
Holly and Justin presented their work at the Department of Rheumatology's grand rounds in March 2023! They did a phenomenal job sharing their work!
Alison received the Jonathan Hack Departmental Award from the Materials Science and Engineering Department in Jan 2023!
Holly and Justin presented their work at the Department of Rheumatology's grand rounds in March 2023! They did a phenomenal job sharing their work!
Alison received the Jonathan Hack Departmental Award from the Materials Science and Engineering Department in Jan 2023!
The Moore Lab held our first Lab Retreat! in Dec. 2022! We traveled to Bradenton to reflect on what we've accomplished and plan for the future!
Congrats to Aakanksha and Justin for passing their preliminary thesis exams!
We continued our tradition of our Lab Giving and had a blast celebrating our lab community!
Dr. Moore becomes the FIRST Black woman to be awarded the BMES Rita Schaffer Young Investigator Award!
Congrats to Aakanksha and Justin for passing their preliminary thesis exams!
Dr. Moore becomes the FIRST Black woman to be awarded the BMES Rita Schaffer Young Investigator Award!
We continue our work on ancestral contributions to monocyte function in lupus with our $600,000 grant from the LRA! Read more here
Aakanksha's article showcases a new biomaterial that helps modulate macrophage phenotype.
Dr. Moore was recently interviewed by UF about this perspective on the importance of considering patient ancestry in the design of biomaterials.
Aakanksha received high praise for her clear and engaging presentation of her work at NC State! This was her first public oral presentation!
Aakanksha's article showcases a new biomaterial that helps modulate macrophage phenotype.
Dr. Moore was recently interviewed by UF about this perspective on the importance of considering patient ancestry in the design of biomaterials.
Aakanksha's article showcases a new biomaterial that helps modulate macrophage phenotype.
Dr. Moore was recently interviewed by UF about this perspective on the importance of considering patient ancestry in the design of biomaterials.
The Moore Lab recently published a new article in Regenerative Engineering and Translational Medicine on the reporting of ancestry in biomedical engineering applications!